As with other types of aspergillus molds, Aspergillus sclerotiorum is found to thrive well in outdoor environments, but does not do well inside homes and other indoor locations. Such a mold type is commonly found in tropical and subtropical soils.

Although Aspergillus sclerotiorum is allergenic, exposure to this mold type does not usually produce life-threatning health effects to humans. However, it should not be discounted that it can affect individuals who are already allergic or asmathic, and contact may induce certain irritations for some people . Human system responses to such a mold type tends to be relatively mild, but responses may also depend on individual sensitivities. Scientific records show that there are no invasive illnesses related to this mold.